Even the most famous one in the world, that of Leonardo Da Vinci (located in Milan in the convent of Santa Maria delle Grazie), was inspired by the Florentine ones.

The term cenacle refers to the room where Jesus ate the Last Supper with the apostles (from the Latin Cenaculum, which derives from 'to dine'), and this is why they are generally located in the refectories of convents (called cenacles), places enveloped in mystical silence. As you explore the many cenacles in Florence, you will not only see marvelous works of art, but you will also find yourself in lesser known and surprising sacred places.

The second, dated 1486, is in the Museo Nazionale di San Marco in Florence, and is called Cenacolo di San Marco. The last of Ghirlandaio's series of three cenacles (the first is in the Badia di Passignano, in Tavarnelle Val di Pesa), it was commissioned by the friars themselves to decorate the smaller refectory where they received guests. 

The Cenacolo di Santo Spirito dates as far back as 1360, and was painted by Andrea Orcagna, a Florentine artist who frescoed the Cappella Maggiore in Santa Maria Novella, completed a century later by Ghirlandaio's workshop. His cenacle is located in the ancient refectory of the Augustinian convent of the Basilica di Santo Spirito, where the Fondazione Salvatore Romano is now based.

The Last Supper of Santa Croce is located in the convent of the basilica of the same name, which gave rise to the Stendhal syndrome, is part of the great work The Tree of Life, Last Supper and Sacred Stories by Taddeo Gaddi of 1355. This Last Supper was mistakenly attributed to Giotto, and is considered the first great Florentine Last Supper.

The Last Supper by Andrea del Castagno (1450), in the spacious refectory of Sant'Apollonia, is one of the earliest examples of Renaissance cenacles, in which the Last Supper is given greater prominence by the placement of the other New Testament episodes at the top, a novelty compared to 14th-century cenacles.